Advances In Spray Drying For Enhanced Bioavailability And Improved Formulation Control

Spray drying has been used extensively in the pharmaceutical industry for a variety of particle engineering applications, including for the manufacture of bioavailability-enhancing formulations such as spray dried dispersions (SDDs) of drugs and polymers, more generally termed amorphous solid dispersions (ASDs). The process is continuous and readily scalable to accommodate the needs of a program, from early feasibility assessments through large-scale commercial launch. Spray dried powders can be readily converted to solid dosage forms for oral dosing, or dosed as dry powders with a specified device for inhaled applications.

In a recent webinar, experts from Lonza discussed the process Lonza uses to develop a spray dried powder formulation and scale that formulation from early feasibility studies to commercial manufacturing. The webinar focused on developments to enable processing of extremely poorly soluble molecules into drug-polymer amorphous dispersions for oral bioavailability enhancement.