BCS Class IV drugs have low solubility and permeability. Oral nanoparticles can overcome both barriers, offering a more effective and tunable oral delivery strategy.
- AI: The Inflection Point In Retinal Drug Discovery, Development, And Delivery
- Reformulating An In-Clinic IV To At-Home Injection Puts Patients At The Center
- AI, Digitalization, And In Vivo Programming Redefine Cell And Gene Therapy
- Minding The Gap: Submission Strategies For Combined Use Combination Products
- Advances In Precision Delivery In CNS Oncology
- Drug-Device Combination Products: 4 Evolving Platforms For 2026
- A Case Study: Control Strategies For A Multi-Dose Pen Injector
- Control Strategies For Injectable Drug Delivery Combination Products
ARTICLES, APP NOTES, CASE STUDIES, & WHITE PAPERS
-
An Insoluble Problem? Oral Drug Solubility With Functional Polymers
Review the basics of solubility enhancement and the formulation and manufacture of products that enhance solubility and common questions on the topic.
-
Bringing A Biosimilar For Oncology To Market: Injectable Packaging From Early Development To Commercialization
While in their early-stage development of a mAb biosimilar for oncology treatment, a large biopharmaceuticals company sought a packaging recommendation: a stopper to maintain high-quality standards.
-
Capsule Formulation Development: From Dosage Forms To Filling
Capsules are tasteless and easy to take, offer streamlined development timelines, and simplicity of manufacturing. Discover capsule formulation development and the benefits of capsule dosage forms.
-
FAQs On The Revised EU GMP Annex 1: Volume 1
The revised GMP Annex 1 guidelines emphasize quality risk management, enhanced environmental monitoring, and data integrity, which aim to minimize contamination and ensure patient safety.
-
Formulation Research Strategy For Discovery- Stage New Drug Candidates
Early stage formulation studies, which should support the emerging target product profile, will often yield important experimental results to aid subsequent development of clinically relevant dosage forms.
-
Overcome Common Pre-Filled Syringe Challenges Through Partnership
The pre-filled syringe space is one of the fastest growing pharma sectors, offering greater patient safety and lower manufacturing costs. But pre-filled doesn’t translate to easily filled; there are particular obstacles to overcome.
-
Steps To Overcome Challenges Associated With Biologic Formulation Development
Explore guidance on the challenges posed by biologics, including overcoming degradation, establishing a stress test process, and the value of lipid nanoparticles (LNPs) and polymeric nanoparticles (NPs).
-
Aseptic Filling And Processing Considerations For Biosimilars
One of the most intriguing, high-stakes aspects of R&D is the realm of biosimilars. Explore the challenges of biosimilar production as well as aseptic processing considerations for biosimilars.
-
Establishing And Safeguarding Shelf Life In Combination Products
Establishing combination product shelf life requires aligning stability. Holistic, data-driven stability studies ensure product function, safety, and label claims through the entire supply chain.
-
Design And Packaging Advantages For Cell And Gene Therapy Drugs
With the increasing demand for cell and gene therapies, Crystal Zenith nested vials can help the biopharma industry overcome the challenges of scaling up manufacturing and logistics.
TOM'S TAKES ON DRUG DELIVERY
TALKING WITH TOM VIDEOCASTS
DELIVERED BY DEGRAZIO
-
6 Packaging And Delivery Challenges For Biologic Therapies
In this article, Fran DeGrazio identifies six aspects of biologics-based therapy packaging and delivery that, if addressed, may help to ensure successful product development and lifecycle management. They include 1) chemical compatibility with device functionality, 2) long-acting formulations, 3) product stability, 4) primary packaging and device integration, 5) cold storage, and 6) higher concentrations and viscosities.

