By leveraging supercritical CO2 as part of the recrystallization method, CESS® permits a green particle engineering process free from excipients and organic solvents while enabling key benefits such as:
- Controlled particle size: by tuning particle size, CESS® allows you to tailor bioavailability and opens up novel opportunities for patient-centricity based on performance requirements
- Controlled particle morphology: manipulating particle morphology enables increased formulation flexibility
- Controlled polymorphism: CESS® provides better polymorph selection and can allow the generation of specific polymorphs independent of nanoparticle size
Nanoform’s CESS® technology has demonstrated its applicability for enhancing therapeutics. For example, in Nanoform’s collaboration with TargTex, the nanoformed API demonstrated superior properties and enabled a fivefold increase in drug load compared to that obtained by nanomilling.
(click to enlarge)
It has also been used in a benchmarking study with Johnson Matthey, where nanoformed particles exhibited improved dissolution performance relative to other comparable processes.
To learn more about how our CESS® technology can help unlock the full potential of your small-molecule drugs, get in touch.