Customized Release Through Dispersed Dosage Formats: Driving Patient Acceptance And Therapeutic Performance

By Nathan Dormer, PhD, Director of Drug Development

Controlled or modified release indicates that the entire drug release is not immediate (i.e., 85% in 30 minutes or less). Drug release profiles can be immediate, delayed immediate, sustained, or delayed sustained; dispersed formats also exist that can achieve each profile.

Even within sustained release, diffusion- and erosion-based systems can approximate asymptotic- and linear/zero-order-profiles, respectively. “Loading” doses are sometimes used to get therapeutics on-board immediately, while the rest is sustained or delayed. Thus, specific release profiles are accomplished by applying purpose-built technologies and different combinations of materials in specific configurations; this can be done for dispersed dosage formats just as well as tablets.

In addition to standard tablet and capsule manufacturing, Adare offers an extensive line of proprietary technology solutions. These technologies have been specifically designed to maintain the dosage form benefits of larger tablets and capsules (e.g. modified release, taste-masking, high drug loading) while leveraging dispersed or non-standard oral formats. We do not believe drug developers (or, ultimately, patients) should have to choose between performance and dosage format when both are a priority.