Developing An Effective Lipid Nanoparticle Formulation Process For Small Molecule And Biologicals Delivery

Lipid nanoparticles (LNPs) are a versatile formulation technology used by drug development teams to deliver a variety of small/large molecules, peptides, and biologicals. Due to a lipid’s unique properties and excellent biocompatibility, LNPs are used in pharmaceuticals, nanomedicines, vaccines, nutritional supplements, and diagnostics by different routes of administration, such as oral, topical, pulmonary, and parenteral injection.

LNPs have emerged as a drug delivery system for biologicals. This is particularly true for COVID-19 mRNA vaccines, as LNPs serve a vital role in transporting mRNA into the target cells.

For these reasons, CDMOs with LNP expertise can prove to be a valuable partner who can help push drugs through the pipeline more efficiently. Ascendia Pharmaceuticals team of scientists has established a general guide and practice process to select LNPs for different types of therapeutic moiety.

This article reviews:

• Liquid-Form LNP Types
• Comparting Solid and Liquid Lipid Nanoparticles
• Process for SLN/NLC
• Liposomes and Lipoplexes
• Cationic Lipids
• Liposome Preparation Methods