Liposomes – Challenges And Opportunities

Source: Pfizer CentreOne Development and Manufacturing

Liposome technology is an important drug delivery tool for maximizing the therapeutic effectiveness of the drugs given. While factors such as relative ease of synthesis, biocompatibility, the ability to load both hydrophilic and hydrophobic agents, and long circulation property after application of polyethylene glycol (PEG) help to improve efficacy and/or reduce the toxicity of the drug used, the chemical and physical stability of liposomes can be problematic, leading to issues with handling and storage. Their short survival time in the body has also been considered a limitation.

Learn more about the challenges facing developers and the opportunities for advancement in manipulating the properties of liposomes to maximize their usefulness.

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