Recent Innovations And Enhancements To Pharmaceutical Spray Drying

Recent advances in spray drying have allowed for additional degrees of freedom in selecting solution compositions to avoid solvents that are either hard to remove from the spray dried powders, are not compendial, or are environmentally harmful and challenging to achieve from a waste management perspective. Lonza, a global contract development and manufacturing organization (CDMO), possesses a wealth of expertise in spray drying, including recent advancements in simultaneous spray drying for combination dry powder formulations to treat lung cancer.

In a recent webinar, “Pharmaceutical Spray Drying: Sustainable Commercial Best Practices to Continuous Project-Focused Innovation,” experts from Lonza explored the spray drying process, including recent enhancements and the approach that Lonza uses to scale up programs using this technology, as well as recent developments to enable processing of extremely poorly soluble (aqueous and organic) molecules into amorphous dispersions for oral bioavailability enhancement. This webinar also explored heated solution processing approaches, novel solvents, and solution preparation techniques that can be used to process extremely poorly soluble molecules or eliminate the need to use undesirable solvents such as tetrahydrofuran (THF) and dichloromethane (DCM).