Inhalation Drug Delivery Resources

1. Formulation Development From Preclinical To First-In-Human 1/24/2022

   A compound with poor biopharmaceutical properties or improper formulation design could lead to a delay in the project or even program termination.

2. Application Of A Novel Temperature Shift Process For Particle Engineering

   Spray drying of amorphous dispersions improves solubility and bioavailability, enabling supersaturation in the intestine and driving higher absorption rates when compared to crystalline drug forms.

3. Improve Solubility And Spray Drying Throughput For Brick Dust Compounds

   This paper presents three approaches to address poor solubility in organic solvents for spray drying as well as case studies outlining their successful application during development.

4. Simultaneous Spray Drying For Combination Dry Powder Inhaler Formulations 7/12/2022

   Three combination case studies are demonstrated, in which bevacizumab is paired with erlotinib, cisplatin, or paclitaxel in a dry powder inhaler formulation.

5. New Technologies To Improve Solubility Of Brick Dust Compounds 7/13/2022

   David Lyon, Ph.D., and Molly Adam answer attendee questions from a recent webinar about three enabling technologies designed to improve drug solubility in organic solvents for spray drying.

6. Six Inhaler Sustainability Myths – And Why They Must Be Busted 3/9/2022

   The solution to the carbon footprint of respiratory disease is complicated. The prevailing “myths” must be examined and addressed to achieve the shared industry vision of a decarbonized inhaler market.

7. Precision Powder-In-Capsule Micro-Dosing Accelerates Drug Development 6/1/2022

   Precision powder microdosing makes it possible to quickly get formulations to the clinic, saving time, money, and use of limited APIs.

8. Simultaneous Spray Drying For Large/Small Mol Combinations 8/9/2022

   Gain insights into a “simul-spray” process pioneering for combining small and large molecules into a single, atomized drug product for inhalation administration.

9. Streamlining The Path To Market For Generic Drug-Device Combinations 9/18/2024

   Developing g-DDCPs is a complex and time-consuming process. By using a risk-based approach, manufacturers can streamline the development process and bring g-DDCPs to market more quickly.

10. Expanding Opportunities For Inhaled Drug Delivery 7/11/2025

    Review the challenges and intricacies of effectively delivering drugs to the lung and the advantages of using nanoparticles and gentle particle processing techniques to enable delivery of sensitive drugs.