Inhalation Drug Delivery Resources

1. Application Of A Novel Temperature Shift Process For Particle Engineering

   Spray drying of amorphous dispersions improves solubility and bioavailability that enables supersaturation in the intestine, driving higher rates of absorption when compared to crystalline drug forms.

2. Emerging Trends And Opportunities In Orally Inhaled Drug Products 3/8/2024

   From targeting niche diseases to delivering cutting-edge medications, inhaled therapies are poised to become a cornerstone of modern medicine. Explore the intricacies of inhaled drug delivery.

3. Spray Drying For Improved Solubility 11/15/2022

   In a recent webinar, experts discussed how to develop a spray dried powder formulation and scale it from early feasibility studies to commercial manufacturing.

4. Application Of Nano-Emulsion Technology To Address Unmet Medical Needs: A Case Study Of Clopidogrel IV By 505(b)(2) Pathway 1/26/2022

   Review a process where the insoluble and unstable free-base form of clopidogrel is converted to a form with acceptable drug loading and is protected from chemical degradation.

5. Formulation Research Strategy For Discovery- Stage New Drug Candidates 1/24/2022

   Early stage formulation studies, which should support the emerging target product profile, will often yield important experimental results to aid subsequent development of clinically relevant dosage forms.

6. Engineering Approaches To Respiratory Drug Delivery 5/27/2022

   Explore the material and performance properties of spray-dried and jet-milled mannitol for respiratory delivery of crystalline mannitol.

7. Precision Powder-In-Capsule Micro-Dosing Accelerates Drug Development 6/1/2022

   Precision powder microdosing makes it possible to quickly get formulations to the clinic, saving time, money, and use of limited APIs.

8. Mitigating Hidden Risks: Extractables And Leachables 1/24/2022

   Everything from glass or plastic bottles to the ink used in labels can leach unwanted contaminants. The first challenge chemists address is to narrow the focus on the most likely suspects.

9. Complex Molecules, Complex Problems

   The support of an experienced CDMO is critical to overcoming complexity when working with a highly potent active pharmaceutical ingredient (HPAPI) and when solving solubility challenges.

10. Simultaneous Spray Drying For Innovative Dry Powder Inhaler Combination Formulations

    Dr. Kimberly Shepard, a principal R&D engineer at Lonza, offered insights on recent innovations pioneered in spray drying. Shepard also discussed spray drying technologies capable of combining small-molecule APIs with biotherapeutic molecules.