Inhalation Drug Delivery Resources

1. Drug Formulation Development: Quick Reference Guide 7/11/2022

   This guide shares the steps involved in formulation development, considerations during formulation, and how partnering with an experienced CDMO can lead to a successful commercial product.

2. Expanding Opportunities For Inhaled Drug Delivery 7/11/2025

   Review the challenges and intricacies of effectively delivering drugs to the lung and the advantages of using nanoparticles and gentle particle processing techniques to enable delivery of sensitive drugs.

3. Mitigating Hidden Risks: Extractables And Leachables 1/24/2022

   Everything from glass or plastic bottles to the ink used in labels can leach unwanted contaminants. The first challenge chemists address is to narrow the focus on the most likely suspects.

4. Examining The Emergence Of Unit- And Bi-Dose Nasal Sprays 2/8/2022

   Nasal spray administration of medicine offers advantages over oral and IV delivery. Experts discuss the advantages and opportunities of adopting unit- and bi-dose nasal delivery technology.

5. Driving Sustainability In Spray Drying Through Enabling Technologies

   By transitioning to alternative solvents or leveraging process aids, the challenges associated with the use of these chemicals can be addressed, helping create a sustainable, greener footprint.

6. Simultaneous Spray Drying For Innovative Dry Powder Inhaler Combination Formulations

   Dr. Kimberly Shepard, a principal R&D engineer at Lonza, offered insights on recent innovations pioneered in spray drying. Shepard also discussed spray drying technologies capable of combining small-molecule APIs with biotherapeutic molecules.

7. Improve Solubility And Spray Drying Throughput For Brick Dust Compounds

   This paper presents three approaches to address poor solubility in organic solvents for spray drying as well as case studies outlining their successful application during development.

8. Spray Drying For Improved Solubility 11/15/2022

   Gain expert insights into how to develop a spray dried powder formulation and scale it from early feasibility studies to commercial manufacturing.

9. Precision Powder-In-Capsule Micro-Dosing Accelerates Drug Development 6/1/2022

   Precision powder microdosing makes it possible to quickly get formulations to the clinic, saving time, money, and use of limited APIs.

10. Simultaneous Spray Drying For Combination Dry Powder Inhaler Formulations 7/12/2022

    Three combination case studies are demonstrated, in which bevacizumab is paired with erlotinib, cisplatin, or paclitaxel in a dry powder inhaler formulation.