Inhalation Drug Delivery Resources

1. Engineering Approaches To Respiratory Drug Delivery 5/27/2022

   Explore the material and performance properties of spray-dried and jet-milled mannitol for respiratory delivery of crystalline mannitol.

2. Simultaneous Spray Drying For Combination Dry Powder Inhaler Formulations 7/12/2022

   Three combination case studies are demonstrated, in which bevacizumab is paired with erlotinib, cisplatin, or paclitaxel in a dry powder inhaler formulation.

3. Is Your Combination Product Drug-Led Or Device-Led? 11/30/2022

   The $118 billion combination-product market is projected to increase at a CAGR of 8.8%. This article answers the question: “Is this actually a combination product? What do we need to do if it is?”

4. Understanding The In-Vitro/In-Vivo Relationship (IVIVR): Inhaled Medicinal Products 11/8/2021

   IVIVR modeling leverages in-vitro testing knowledge toward predicting in-vivo testing results, often reducing long-term development costs by facilitating more informed decision-making during drug development.

5. Simultaneous Spray Drying For Innovative Dry Powder Inhaler Combination Formulations

   Dr. Kimberly Shepard, a principal R&D engineer at Lonza, offered insights on recent innovations pioneered in spray drying. Shepard also discussed spray drying technologies capable of combining small-molecule APIs with biotherapeutic molecules.

6. Formulation Research Strategy For Discovery- Stage New Drug Candidates 1/24/2022

   Early stage formulation studies, which should support the emerging target product profile, will often yield important experimental results to aid subsequent development of clinically relevant dosage forms.

7. Promising Early Results For New High-Performance DPI 4/28/2022

   This report discusses the benefits of the αeolus technology, a passive, high-performance, high-consistency dry powder inhaler platform concept, and the preliminary performance data from early-stage development.

8. Mitigating Hidden Risks: Extractables And Leachables 1/24/2022

   Everything from glass or plastic bottles to the ink used in labels can leach unwanted contaminants. The first challenge chemists address is to narrow the focus on the most likely suspects.

9. Spray Drying For Improved Solubility 11/15/2022

   Gain expert insights into how to develop a spray dried powder formulation and scale it from early feasibility studies to commercial manufacturing.

10. Intranasal Drug Product Development—From Formulation To Scale-Up Manufacturing 3/8/2024

    Explore the key advantages of intranasal drug delivery, including its potential to rapidly treat conditions like migraines and headaches, and deliver medications directly to the brain.