Oral Drug Delivery Resources

1. Capsule Formulation Development: From Dosage Forms To Filling 5/4/2022

   Capsules are tasteless and easy to take, offer streamlined development timelines, and simplicity of manufacturing. Discover capsule formulation development and the benefits of capsule dosage forms.

2. Formulation Research Strategy For Discovery- Stage New Drug Candidates 1/24/2022

   Early stage formulation studies, which should support the emerging target product profile, will often yield important experimental results to aid subsequent development of clinically relevant dosage forms.

3. A Clinical Assessment Of Delayed-Release Coated Capsule Compositions For Regional Gastrointestinal Delivery Using Gamma Scintigraphy 3/7/2022

   Gamma scintigraphy was used to evaluate GI transit and release from 3 capsule prototypes with different coating systems; data on pH, temperature and pressure during GI transit was obtained and correlated.

4. Crystallization Process Dev: Ramping Up Bench-Scale Control 1/20/2022

   Since physical structure and biological activity are directly linked, controlling the physical form of a compound is paramount to a final drug product’s quality and effectiveness.

5. Considerations In Development & Manufacturing Of Complex Injectables For Early Phase Studies 2/7/2022

   A niche CDMO, with specialized technologies in complex injectable development, will have greater flexibility for successful manufacture of complex injectables in early phase development of therapeutic drugs.

6. Solutions For Challenging Compounds Using Softgel Innovation 5/5/2017

   The significant interest in semi-solid systems for the potential of extended release profiles has prompted researchers to develop alternative encapsulating systems. 

7. Are Drugs Becoming More Lipophilic Over Time?

   Get a deeper look into how drug lipophilicity has evolved over time, its impact on drug development, and the need for new technology to enable new more complex drugs.

8. Strategies For De-Risking Early-Phase Oral Small Molecule Drug Development 3/7/2022

   A team of experts discuss risk-reduction strategies, critical formulation considerations, and careful technology selection to stretch the often limited quantities of API available for early studies.

9. Maintaining Drug Bioavailability And Masking Taste With Microencapsulation 8/24/2022

   Several technologies are available for microencapsulating drugs. Finding the right CDMO to optimize a drug’s efficacy and manufacturing during formulation is integral to its clinical and commercial success.

10. Optimizing Formulations With Bioavailability Enhancement Technologies

    API-sparing development techniques and identifying the appropriate scalable formulation technology to improve drug solubility and enhance oral bioavailability can help increase your chances of success.