Oral Drug Delivery Resources

31. Enhancing The Solubility Of High Lipophilicity Drugs Via Spray Drying 3/10/2023

    A new R&D project shows the solubility and dissolution characteristics of Itraconazole can be improved by helping them maintain an amorphous state after spray drying with selected hydrophilic polymers.

32. How To Leverage Modeling And Simulation In The Candidate Development Stage

    Modeling and simulation provides another way to predict the clinical performance of a molecule, based on a robust and holistic approach, before investing the required time and money.

33. 4 Factors Affecting Solubility Of Drugs 2/28/2022

    Improper drug solubility can lead to suboptimal drug delivery and absorption, resulting in ineffective drug efficacy and side effects, so solubility must be evaluated in the early stages of drug discovery.

34. Are Drugs Becoming More Lipophilic Over Time?

    Get a deeper look into how drug lipophilicity has evolved over time, its impact on drug development, and the need for new technology to enable new more complex drugs.

35. An Integrated Radiolabelled Study: Determine Mass Balance Metabolite Profile & Absolute Bioavailability 3/3/2022

    The study assessed the absorption and disposition of nolasiban after oral and IV administrations and enabled determination of mass balance, routes and rates of excretion and metabolism and absolute bioavailability.

36. Advances In Spray Drying For Enhanced Bioavailability And Improved Formulation Control

    In a recent webinar, Lonza discussed the process it uses to develop a spray dried powder formulation and scale from early feasibility studies to manufacturing.

37. Optimizing Highly Potent API Drug Development And Manufacturing 3/10/2025

    Through expert insights and real-world case studies, this resource provides valuable perspectives on optimizing HPAPI workflows, ensuring compliance, and leveraging process advancements.

38. Reducing Environmental Impact At All Stages Of The Medicine Journey

    Explore how utilizing technologies like AI and digital twinning can inform decision-making at the R&D stage and how to optimize the delivery of the final drug product to patients with greener logistics.

39. Overcoming Supply Chain Roadblocks To Ensure Reliable Complex OSD Delivery 2/26/2024

    Ensuring critical oral solid dosage (OSD) therapeutics reach patients successfully relies on the ability of developers and manufacturers to navigate the inherent issues surrounding their increasing complexity.

40. Precision Powder-In-Capsule Micro-Dosing Accelerates Drug Development 6/1/2022

    Precision powder microdosing makes it possible to quickly get formulations to the clinic, saving time, money, and use of limited APIs.