Oral Drug Delivery Resources

  1. Drug Formulation Development: Quick Reference Guide 7/11/2022

    This guide shares the steps involved in formulation development, considerations during formulation, and how partnering with an experienced CDMO can lead to a successful commercial product.

  2. Spray Drying For Improved Solubility 11/15/2022

    Gain expert insights into how to develop a spray dried powder formulation and scale it from early feasibility studies to commercial manufacturing.

  3. Customized Release Through Dispersed Dosage Formats 6/13/2024

    Typically, dosage format is based on the target product profile: how the developer envisions the product best addressing a clinical indication by maintaining population-wide efficacy.

  4. Strategies For De-Risking Early-Phase Oral Small Molecule Drug Development 3/7/2022

    A team of experts discuss risk-reduction strategies, critical formulation considerations, and careful technology selection to stretch the often limited quantities of API available for early studies.

  5. Semi-Solid And Semi-Liquid Dosage Forms: What To Know 3/7/2023

    Interest in semi-solid dose (SSD) forms has been on the rise. Learn more about the advantages of formulating medications into SSD forms as well as the challenges to consider.

  6. Oral Controlled Delivery Of Poorly Water-Soluble Drugs 1/27/2022

    Various drug delivery nanotechnologies, such as nano-suspensions, lipid microemulsions, nano-emulsions, and amorphous solid dispersions, have been critical in overcoming bioavailability challenges.

  7. Nanosuspension Dosage Forms: Product Development & Scale Up 2/8/2022

    For drug nanosuspensions, parameters like stabilizer concentration, drug loading, milling speed, milling time, bead diameter/density, and temperature are important formulation and process variables.

  8. Pediatric Patient Considerations During Dose Development

    Specific dosing guidelines and acceptable dosage forms for pediatric patients need to be developed to optimize therapeutic efficacy and limit and prevent serious adverse side effects.

  9. Benefits Of Microparticle Technology For Oral Drug Solubility Enhancement 6/8/2022

    Spray-dried dispersions, hot-melt extrusion, and solubilizing excipients are common solubility enhancement techniques, but new developments to maximize amorphous solid dispersion benefits are needed.

  10. Innovative Formulation Technologies By 505(b)(2) Regulatory Pathway 1/24/2022

    Revitalization of older marketed drugs using innovative drug delivery technologies can provide new marketing exclusivity and patent protection, offering an effective tool for product life cycle management.